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Ion channel family
Transmembrane ion channel family was defined in InterPro and Pfam as the family of tetrameric sodium, potassium, and calcium ion channels, in which two C-terminal transmembrane helices flank a loop which determines ion selectivity of the channel pore. This large group of ion channels apparently includes families , , , and of transporter classification.
Many eukaryotic channels have four additional transmembrane helices (TMH) (), whereas a bacterial structure of the protein has only two transmembrane helices that form the tetrameric channel ().
==Human channels with 6 TM helices ==
Cation
* MCOLN1; MCOLN2; MCOLN3;
* PKD1L3;
* TRPA1
* TPCN1; TPCN2
* TRPC1: TRPC3; TRPC4; TRPC5; TRPC6; TRPC7
* TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8
* TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6
Calcium
* CACNA1A; CACNA1B; CACNA1C; CACNA1D; CACNA1E; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S
* CATSPER1; CATSPER2; CATSPER3; CATSPER4
* RYR1; RYR2; RYR3
Potassium
* KCNA1; KCNA2; KCNA3; KCNA4; KCNA5; KCNA6; KCNA7; KCNA10
* KCNB1; KCNB2
* KCNC1; KCNC2; KCNC3; KCNC4
* KCND1; KCND2; KCND3
* KCNF1
* KCNG1; KCNG2; KCNG3; KCNG4
* KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNH8
* KCNMA1
* KCNQ1; KCNQ2; KCNQ3; KCNQ4; KCNQ5
* KCNS1; KCNS2; KCNS3
* KCNV1; KCNV2
Sodium
* NALCN
* SCN1A; SCN2A; SCN2A2; SCN3A; SCN4A; SCN5A; SCN7A; SCN8A; SCN9A; SCN10A; SCN11A
* SLC9A10; SLC9A11
Proton
* HVCN1
Cyclic nucleotide-gated
* CNGA1; CNGA2; CNGA3; CNGA4
* CNGB1; CNGB3
* HCN1; HCN2; HCN3; HCN4
* ITPR1; ITPR2; ITPR3
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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